Research Summary Archives

  This article at a glance Prevention of Alzheimer’s disease by intervention at earlier stages of cognitive decline is increasingly viewed as an alternative approach to the not yet achieved successful treatment of Alzheimer’s disease.This exploratoy study makes a preliminary evaluation of neuron...

This article at a glance Is it possible that the quality of food during gestation and around birth sets the stage for the eating behaviour of the offspring when they become adults? This study reports that in mice a perinatal deficiency in dietary omega-3 fatty acids has long-lasting effects int...

This article at a glance This study addressed the potential effectiveness of daily EPA/DHA for migraine headaches in adults with chronic migraine also taking low-dose amitriptyline, a drug used for migraine prevention. Participants taking both EPA/DHA and amitriptyline for 2 months reported a m...

This article at a glance The hippocampal-prefrontal cortex (H-PFC) pathway is a neuronal circuit that is central to integrating working memory with contextual information, facilitating executive function, such as making decisions. A recent neuroscience study in the rat reports that enzymatic co...

  Barbara J Meyer (University of Wollongong, Australia) Dilys J Freeman (University of Glasgow, UK)   Docosahexaenoic acid (DHA) and polyunsaturated fatty acid (PUFA) metabolism DHA is an omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) containing 22 carbons and 6 carbon to ca...

This article at a glance Psychotic disorders encompass serious psychiatric disorders, manifesting themselves in the altered perception of reality, such as delusions or hallucinations, disorganized or bizarre behaviors and “negative” symptoms, which include flatness of emotion and interperso...

This article at a glance In an observational study of a cohort of Puerto Ricans, only those individuals with the highest level of urinary 8-hydroxy-2´-deoxyguanosine (8-OHdG), a marker of oxidative stress, showed an inverse relationship between the omega-3 index (combined EPA and DHA as percentag...

Richard P. Bazinet Associate Professor, Canada Research Chair in Brain Lipid Metabolism Department of Nutritional Sciences, Faculty of Medicine, University of Toronto FitzGerald Building, 150 College Street, Room 306 Toronto, ON, Canada M5S 3E2 Email - richard.bazinet@utoronto.ca   The...

This article at a glance Alzheimer’s Disease is an accelerated form of age-related cognitive decline characterized by brain atrophy. This study has uncovered a previously unknown association between higher omega-3 LCPUFA status and the potential for inhibition by supplemental B-vitamin intak...

Epilepsy is a disorder of the central nervous system (CNS) in which individuals experience epileptic seizures, displays of transient deregulated neural activity in one or both hemispheres. Epileptic activity displays as changes in sensory awareness and involuntary motor activation of specific b...

The brain is rich in docosahexaenoic acid (DHA). This fatty acid is a structural element for brain tissue, plays a number of important roles in neural development and plasticity, and protects the brain from inflammatory insult. The brain is relatively separated from the rest of the body by the prese...

Malnutrition, defined by insufficient energy and protein intake, seriously affects cognitive functions. Nutritional deficiencies early in a child’s development have marked consequences for cognitive development and overall growth at later ages of development. Malnutrition is a preventable malady but...